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KMID : 0363220140520010001
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Korean Journal of Dermatology
2014 Volume.52 No. 1 p.1 ~ p.6
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Effect of Horse Oil on Anti-bacterial, Inflammatory Cytokines, and Type I Collagen Expressions in Human HaCaT Keratinocytes and Fibroblasts
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Choi Kyoung-Hwa
Lee Young-Sun
Yoon Ji-Hyun
Yoo Wang-Keun
Kim Mi-Rye
Lee Kyu-Suk
Cho Jae-We
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Abstract
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Background: Anti-inflammation, anti-bactericidal, and collagen synthesis are important for health skin conditions. However, the effect of horse oil on anti-inflammation, anti-bactericidal, and collagen synthesis is largely unknown. Objective: The aim of this study was to evaluate the anti-bactericidal, anti-inflammatory, and synthesis of type Icollagen of horse oil.
Methods: Anti-bacterial effect was evaluated by disc diffusion test. Expressions of inflammatory cytokines werestudied by RT-PCR analysis, real time PCR. Type I collagen expression was evaluated by Western blot in humanHaCaT kertinocytes and fibroblasts.
Results: Our data showed that horse oil exerted anti-bacterial effect on P.acnes and S.aureus. Expression of IL-10was increased by horse oil-treated HaCaT cells. In addition, increased expression of type I collagen was observedin horse oil-treated human skin fibroblasts.
Conclusion: Horse oil exerts an anti-bactericidal effect against P.acnes and S.aureus. In addition, anti-inflammatoryand anti-aging effects of horse oil will be mediated by up-regulation of IL-10 and type I collagen, respectively.
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KEYWORD
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Anti-bactericidal effect, Horse oil, IL-10, Type I collagen
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